Novel Compounds May Battle Diseases of Aging

Experimental compounds aimed at treating diseases such as type 2 diabetes show promise, scientists say.

These “novel chemical entities” activate SIRT1, a gene controlling the aging process, the researchers report in the Nov. 29 issue of Nature.

In obese mice, these compounds improved insulin sensitivity, lowered plasma glucose levels, and increased the function of mitochondria (the powerhouse of cells).

In rats, the compounds improved whole body glucose homeostasis and insulin sensitivity in fat tissue, skeletal muscle, and the liver.  The experimental compounds were developed and tested by Sirtris Pharmaceuticals Inc., in Cambridge, Mass.

Source:  Washington Post

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