Younger for longer

Severe calorie restriction extends life-span in mice and other species, but how near-starvation can prolong life remained a mystery.

Now at last, specific links between calorie restriction and longevity have been found in that workhorse of ageing research, the nematode C. elegans

Nicholas Bishop and Leonard Guarente find that dietary restriction activates transcription factor SKN-1 in ASI neurons in the head, which signal peripheral tissues to increase metabolic activity, a mechanism suggestive of the involvement of an endocrine system.

Source:  Nature (registration required)

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