Mice just got a little more human

Scientific American on how researchers have successfully reproduced a human blood disease in mice for the first time by swapping out a larger-than-normal portion of the mouse genome for the equivalent human DNA.

The technology, which exchanges both a gene and the region of the genome around it, may allow geneticists to overcome some of the current obstacles to studying human disease in mice.

Researchers already knew how to trade a single mouse gene for its human counterpart to create a transgenic mouse. But the activity of a gene is also regulated by bits of DNA outside of the gene. The problem the field faced was that the equivalent gene could be regulated a different way in the mouse than it had been in humans.

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